Lyon-Vaise station (French pronunciation: [ljɔ̃ vɛz]) is a railway station in Lyon, located in the district of Vaise, in the 9th arrondissement.

From 10 July 1854 until the opening of the Saint-Irenée tunnel between Vaise and Perrache railway station on 10 October 1856, the station was the Lyon terminus of trains from Chalon-sur-Saône and Paris.

It was provisionally rebuilt in wood, then a new station was opened in 1956.

In 1997, a new multimodal space was built to facilitate connections between the train, metro and bus.

The station is served by regional trains towards Mâcon, Nevers, Bourg-en-Bresse, Vienne and Roanne.