[3] Karen Marie Aagaard Ørsted Andersen[4][5] was born in Ubberud, near Odense,[6] and she grew up in Ejlstrup on the island of Funen, Denmark.

[11] In 2006, MØ released a side project titled The Edmunds, which included tracks such as "Garbage King" and "Polly Get Your Gun".

The side-projects included songs that have been previously taken down due to an unknown reason, but has been re-released by a fan on YouTube.

MØ and her friend Josefine Struckmann Pedersen formed duo MOR in 2007, and released two EPs, Fisse I Dit Fjæs ("Pussy in Your Face") and Vanvidstimer ("Madness Hours"), in 2009 and 2011, respectively.

[24] The single "Don't Wanna Dance" debuted on BBC Radio 1 on 16 January 2014 as Zane Lowe's Hottest Record.

[27] Music blog Pretty Much Amazing called the album "complex and euphoric", while The Guardian noted that "what MØ lacks in originality, she makes up for with warlike ardour".

On 2 June 2014, she made her US television debut on Jimmy Kimmel Live!, where she performed the songs "Don't Wanna Dance" and "Pilgrim".

[31] On 23 June, MØ announced additional United States and Canadian tour dates beginning in September.

[36] MØ also co-wrote the song "All My Love" by Major Lazer, featuring vocals from American singer and songwriter Ariana Grande.

[37] MØ co-wrote and provided vocals for another Major Lazer song, "Lean On" with DJ Snake, which was released in March 2015.

[43] On 14 October, the single made its world premiere on a BBC Radio 1 segment hosted by Annie Mac before the studio version was released the following day.

On 13 May 2016, "Final Song", the second single from MØ's second album, was released and also made its world premiere on the same radio segment hosted by Mac.

[44] MØ is the highest-charting Danish act along with Jørgen Ingmann ("Apache") and Lukas Graham ("7 Years"), who all reached number two on the Billboard Hot 100.

[46] On 6 January 2017, English electronic duo Snakehips premiered their new track "Don't Leave" which features vocals from MØ.

[47] On 21 April 2017 "Nights with You", the third single from her upcoming second studio album, was officially released worldwide after premiering on MistaJam's BBC Radio 1 show the previous day.

[49] In 2017, MØ co-wrote and provided vocals on Diplo's song "Get It Right" for the album Major Lazer Presents: Give Me Future.

In 2019, MØ performed her single "Blur" on The Tonight Show Starring Jimmy Fallon, [55] she co-wrote and provided vocals to the theme song for Moominvalley, and was the support act for Panic!

On September 20, 2023, MØ and Fryd Frydendahl published their book titled "RACING – Circles of doubt, Squares of light".

[63] In the anniversary edition of the album she had released three outtakes “Bad Luck”, “Anti Hero” & “Daydreams (Night Version)”.

MØ released her single “Who Said” on October 16, 2024, accompanied by an official visualizer directed by Danish photographer Fryd Frydendahl.

[1] MØ said in an interview from Wonderland Magazine[64] that her grandfather, Mogens Ørsted, who used to be an artist would sign his initials on his paintings.

[71] MØ has described her sound as "an organic yet dynamic mix of electro, indie-pop, soul and street vibes".

[76][77] Her second album, Forever Neverland, was described as electropop and dance-pop, containing elements of tropical house,[78] experimental,[79] trip hop,[80] alternative pop[81] and dancehall.

[82][83][84] MØ's music has been compared to electropop artists Grimes and Twin Shadow, and her vocals to those of Lana Del Rey.