[3][4] On 23 January 2023, Perrone signed a five-and-a-half-year contract with Manchester City for around £8m, and joined the club following the conclusion of the 2023 South American U-20 Championship.

[5][6] On 25 February, he made his Premier League debut in a 4–1 away win over Bournemouth, replacing Erling Haaland in the 72nd minute.

[7] On 23 August 2023, Perrone joined La Liga side Las Palmas on loan for the entirety of the 2023–24 season.

[15] Perrone was once again included in Argentina's squad for the 2023 FIFA U-20 World Cup, where he scored the third goal in a 3–0 group stage win against Guatemala.

[17] In March 2023, he received his first call-up to the Argentina senior national team by head coach Lionel Scaloni for two friendly matches against Panama and Curaçao.