She was a series regular on Central Park West (1995–1996), Freddie (2005–2006), and Witches of East End (2013–2014) and as Wendall Meade in ER (2004).

[citation needed] After moving to Los Angeles, Amick began her career with guest roles on Star Trek: The Next Generation (1989) and Baywatch (1989).

Amick got her first break when director David Lynch chose her to play waitress Shelly Johnson on the television series Twin Peaks (1990–1991).

[6] In 1990, Amick was cast as Mandy in Don't Tell Her It's Me and portrayed Amy in Tobe Hooper's horror film I'm Dangerous Tonight.

In 1993, Amick was cast as Lena Mathers in the feature film Dream Lover, a thriller in which she co-starred with James Spader.

Amick's return to network television came in the fall of 1995 with the much-publicized CBS primetime soap opera Central Park West.

[12] Amick guest-starred in a number of episodes of the serial thriller Kidnapped on NBC, playing a strange and deadly assassin.

[17] In 2013, Amick began starring in the Lifetime supernatural drama Witches of East End opposite Julia Ormond, Rachel Boston and Jenna Dewan.