Ruspoli made her modelling debut in 2014 as one of the faces of Salvatore Ferragamo S.p.A.'s Fiamma campaign.
She made her runway debut for walking for Dolce & Gabbana at Milan Fashion Week in 2017.
Donna Mathilda Mélusine dei Principi Ruspoli was born in Paris on 25 July 1994 to the Italian actor and aristocrat Alessandro Ruspoli, 9th Prince of Cerveteri and the French model Theresa Patricia Genest.
[2][6] In 2013, she was presented to society during Le Bal des Débutantes at the Hôtel Raphael.
[7] In 2017, Ruspoli made her runway modelling debut walking in the Dolce & Gabbana Spring/Summer show at Milan Fashion Week.
[1][19] In 2019, she attended the Animal Ball, a charity event in London that raises funds for conservation programmes in South Asia.