Mézières-en-Santerre (French pronunciation: [mezjɛʁ ɑ̃ sɑ̃tɛʁ], literally Mézières in Santerre; Picard: Mézière-in-Santérre) is a commune in the Somme department in Hauts-de-France in northern France.

The commune is situated on the D28 road, 24 kilometres (15 mi) southeast of Amiens.

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