Mézin (French pronunciation: [mezɛ̃]; Occitan: Mesin) is a commune in the Lot-et-Garonne department in Nouvelle-Aquitaine, south-western France.

It is part of the arrondissement of Nerac.

The Auzoue flows into the Gélise in the commune.

The Gélise forms most of the commune's western border.

This Lot-et-Garonne geographical article is a stub.