Mühlacker station has direct rail connections with Stuttgart, Karlsruhe, Heidelberg, Pforzheim and the Northern Black Forest.

Mühlhausen an der Enz where Spree killer Ernst August Wagner killed 13 people in 1913 has been a part of the city since 1972.

With the opening of the Württemberg Western Railway Stuttgart - Bruchsal in 1853 the industrial age began in the Dürrmenz-Mühlacker area.

Favored by the dismantling of custom barriers 1819-1851 and the abolition of the compulsory guild (1862), industrial enterprises settled near the train station.

The World War II ended in Mühlacker with destruction by air raids and artillery shelling.