The line, which is operated by the Südostbayernbahn (SOB) (part of Deutsche Bahn), runs from Mühldorf to Freilassing in the German state of Bavaria.

In Tüßling a change in the route of the line to Burghausen was made because it was originally planned to build the junction with the branch of the Tauern Railway in Ehring.

The first completed project on the current upgrade of the Mühldorf–Salzburg line was a 160-metre-long concrete bridge over the Inn just south of Mühldorf, which was opened in late September 2011.

Funding is now secured for duplication of the Mühldorf–Tüßling section, including electrification, and the federal transport minister Peter Ramsauer indicated in September 2011 that it would be commissioned in 2016.

In addition, a funding agreement has been reached to provide €50 million for the upgrading of the Rosenheim–Salzburg railway from Freilassing to the Austrian border to three tracks.

[7] The planned upgrade would also bring considerable relief on the Munich–Rosenheim route and therefore would make available additional capacity for freight traffic on the Brenner Railway.