It was renamed as a Hauptbahnhof in 1974 at the time of the rebuilding of the Dortmund–Duisburg line as part of the establishment of the Rhine-Ruhr S-Bahn.

Between 1905 and 1910 a common station with a peaked roof was built to serve both lines, but it was destroyed during World War II and never rebuilt.

During the electrification of the Cologne-Hamm line in the 1950s the stopping place for long-distance trains was moved back to the Eppinghofen station and on 22 May 1955 it was renamed Mülheim (Ruhr) Stadt ("city").

In 1974 the station was relocated with the opening of Rhine-Ruhr S-Bahn and finally renamed Mülheim (Ruhr) Hbf.

The following services currently call at Mülheim Hauptbahnhof:[6][7] The following long-distance trains stopped at the station in 2023.