The original Münster station was opened in 1848 by the Münster-Hamm Railway Company, when it opened by the Münster–Hamm railway to the then capital of the Prussian Province of Westphalia as a terminus of its branch line from Hamm, where it connected with Cologne-Minden trunk line.

The station building was erected in front of the Servatii-Tor (gate) between the modern streets of Wolbecker Straße and Albersloher Weg.

This led to a shortening of travel times, because through trains now ran from Warburg to Munster.

In western Münsterland, at the beginning of the 1860s there were efforts to promote the local economy by building a railway link from Münster via Gronau to Enschede.

Construction began in June 1872, but the Münster-Enschede railway company ran into financial difficulties in 1874.

Already in 1875 the rural municipalities of St. Lamberti and Mauritz had been incorporated into Münster, so it now had planning authority for the station area.

In 1928/30 the station building was rebuilt as a "gateway to the modern city" and the reconstruction was completed at the end of September 1930 for Katholikentag.

After the repair of damaged bridges in the area of Schleuse Münster, trains could also run to Osnabrück again.

This platform has been closed since the abandonment of passenger service on the line to Lippstadt in the winter timetable of 1975.

The plans for the work at the station and adjacent areas were prepared by the Munster-born chief architect of Deutsche Bundesbahn, Theodor Dierksmeier.

The TEA Parsifal express ran from Hamburg to Paris and stopped in Münster.

Starting on 23 July 2012 the private railway company Hamburg-Köln-Express provides up to three intercity train pairs daily along the route Hamburg - Münster - Cologne.

[5] The French rail company SNCF is also thinking about a new TGV lines, including a route from Strasbourg to Frankfurt, Cologne and Münster to Hamburg.