Mỹ Tho (listenⓘ) is a city in the Tiền Giang province in the Mekong Delta region of South Vietnam.

[4] Mỹ Tho was founded in the 1680s by Chinese refugees fleeing China after the fall of remnants of the Southern Ming to the Qing dynasty in 1683.

During the colonization period, the economy continued to prosper, attracting more immigrants, mainly from Teochew and Minnan of mainland China.

By river, there are many short boat trips to various islands, Bến Tre, and floating markets[11] in the surrounding areas.

The Collège de Mỹ Tho, opened in March 1879, is now called Nguyễn Đình Chiểu High School.

Schools in Mỹ Tho are named after famous Vietnamese writers, poets, and national heroes such as Nguyễn Trãi, Thu Khoa Huan is also known as Nguyen Huu Huan, Xuân Diệu, Lê Ngọc Hân, Nguyễn Đình Chiểu, Trần Hưng Đạo.

Today the economy of Mỹ Tho is mainly based on tourism, fishing, and agricultural products such as coconuts, bananas, and longans.

[17] During World War II the French Vichy government interned foreign nationals in Mỹ Tho.

Mỹ Tho was the subject of "The Lesson", a chapter in a memoir by Tobias Wolff, In Pharaoh's Army: Memories of the Lost War, describing the events of the 1968 Tet Offensive there.