Missions include general support, counter-battery fire, and suppression of enemy air defense systems.

Well trained and motivated crews could achieve two to four rounds per minute for short periods by using the manual rammer, essentially a heavy steel pole with a hard rubber pad on one end.

Most of the U.S. Army and Marine Corps relied on M109 series 155-millimeter howitzer systems during this conflict, sending remaining M110s to reserve or National Guard units.

M110s were still in service with the 3rd Battalion 92nd Field Artillery (US Army Reserve) and running fire missions at Camp Atterbury as late as the summer of 1994.

Later, in 1982, Israel used M110 systems against the Palestine Liberation Organization and their Lebanese allies with deadly effect during the Siege of Beirut as part of Operation Peace for Galilee.