It passes through Mayfair and Brixton before travelling through Melville, Roosevelt Park, Northcliff, Blackheath and traversing the N1 Western Bypass at Randpark Ridge.

[3]: 80 The road becomes Beyers Naudé Drive, originally called DF Malan Drive, and passes through a gorge between the eastern & western sections of the Melville Koppies, high ground with views to the northern and southern suburbs of Johannesburg, and the Koppies hold the archaeological record of the original black inhabitants of the Witwatersrand.

[3]: 53  Continuing north-west through Randpark Ridge it crosses over the M6 (Ysterhout Drive) and after 4km it intersects with Christian De Wet Road and Northumberland Avenue together part of the R564.

[3]: 30–31 Passing through Honeydew, the suburb thins as it becomes a set of agricultural holdings but continues north-west as Beyers Naudé Drive and intersects the R114 at a staggered junction near Muldersdrift and shortly thereafter the N14 Pretoria-Krugersdorp freeway.

[4] Passing over the freeway it continues north-east now through more agricultural holdings before ending at its northern terminus as a t-junction with the R540 (Kromdraai Road) after crossing the Crocodile River.