[7] In 2000, Breed starred in the straight-to-video movie, Dollar, alongside Shannon Greer, and released a soundtrack for it, which featured his hit, "Ain't No Future in Yo' Frontin'".

[9] In 2001, Breed released his 13th album, The Fharmacist, with an up-start independent label based out of Detroit, Michigan called Fharmacy Records.

Breed re-emerged in 2004 with a new deal through Urban Music Zone Entertainment, a subsidiary label of Psychopathic Records, to release his album The New Prescription.

[11] The album was released in August of that year with national distribution through RED Distribution/Sony, and featured Esham, who was signed to Psychopathic Records at the time.

[12] On April 3, 2008, he was arrested in Flint, Michigan, following an in-store autograph signing session, on warrants for about $220,000 in unpaid child support.

[16] Although the project was still in development, Breed had reached out to many of his friends to help create the album, such as producers Erotic D, Ant Banks, Jazze Pha, Sonji Mickey, and Colin Wolfe, as well as rappers the D.O.C., Spice 1, and Too Short.