The club plays in the Fortuna Liga, the top tier of Slovak football, and hosts home games at the Mestský štadión Skalica.

MFK Skalica reached Fortuna Liga despite defeat 0:2 by MFK Zemplín Michalovce in closing match of DOXXbet liga on 13 June 2015 and they surprised everyone by securing the second spot in the league and securing the first historical promotion to the highest football tier in Slovakia as well as MFK Zemplín Michalovce.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

For recent transfers, see List of Slovak football transfers summer 2024 and List of Slovak football transfers winter 2024-25 Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players whose name is listed in bold represented their countries while playing for Skalica.