Major League Baseball (MLB) scheduled two games at Estadio Alfredo Harp Helú to be played on April 18–19, 2020, with the Arizona Diamondbacks hosting the San Diego Padres.

[2] The first regular-season games to be played in Mexico City[a] took place during the 2023 season on April 29–30, between the Padres and San Francisco Giants, as part of MLB World Tour (MLB games played outside of the United States and Canada).

[3][4] The crowd was heavily biased towards the Padres, who are based very close to the Mexican border, and attracted fans from the U.S. and from across Mexico.

[5] Due to the high altitude and hitter-friendly dimensions of the stadium, the first game included 11 home runs from 10 different players, tying an MLB record.

[8] For the 2024 season, MLB announced two games between the Houston Astros and Colorado Rockies, scheduled for April 27–28.