[1] In March 2022, it was reported by The Wall Street Journal that NBC Sports was finalizing an agreement to establish a new package of Sunday afternoon games beginning in the 2022 MLB season.

[2] As a prelude to the deal, Peacock had exclusively aired a June 2021 series between the Philadelphia Phillies and San Francisco Giants.

It was co-produced by NBC Sports Bay Area and NBC Sports Philadelphia, and featured a broadcast team led by the Giants' lead play-by-play announcer Jon Miller and his partner Mike Krukow, joined by the Phillies' analysts John Kruk and Jimmy Rollins.

[6][7] On April 13, 2022, NBC Sports announced that the games would be branded as MLB Sunday Leadoff.

In Canada, the Toronto Blue Jays' appearances were televised as normal by MLB's Canadian broadcast partner Sportsnet, as part of its regional rights to the team.

[10] The broadcasts were described as being "hyperlocal" with a "national flair", being built upon the on-air presentation for NBC Sports' regional MLB coverage.

[13] Jason Benetti (who calls Chicago White Sox games for NBC Sports Chicago, and also worked NBC's telecasts of baseball during the 2020 Summer Olympics)[14] served as the lead by-play announcer for the 2022 season, joined by rotating analysts from each participating team.

[18][19] Brendan Burke replaced Benetti as the lead play-by-play announcer for MLB Sunday Leadoff in 2023.