The festival started in 2006 with a concert at Launceston's Regatta Ground to mark the 50th anniversary of the MS Society.

Over the years of operation Opcon attempted to negotiate an arrangement with the MS Society of Tasmania that would be sustainable and respectful of the huge financial risk the company was undertaking to deliver the event.

This and the opportunity to host the event at such an iconic and pristine venue such as the TCA grounds in Hobart made this the clear and sensible choice for MS Tasmania.

[5] The 2006 festival was the first installment of MS Fest, held on Saturday, 11 March 2006 at the Royal Park Regatta Grounds, Launceston.

The festival was cancelled in early 2012 due to low ticket sales and poor weather predictions.