This service allows passengers in the Britannia staterooms to have single seating dining arrangements, without having to upgrade to the more expensive Grills classes.

[9] The ceremony was held in Southampton on 11 October 2010 before the ship set sail on her maiden voyage to the Canary Islands the following day.

[14] At the end of October 2011 Queen Elizabeth and her fleet mates were registered to Hamilton, Bermuda, in order to host weddings aboard.

[18] On 12 March 2013 the cruise ship passed the former Cunard liner Queen Mary, then a hotel in Long Beach, California, for the first time along with fireworks display.

[24] On 20 December 2014 Queen Elizabeth on a four night cruise was unable to dock in Amsterdam due to stormy conditions and was forced to circle in the English channel before returning to Southampton early.

[25] In April 2015 while visiting Sihanoukville, Cambodia a passenger died on the Queen Elizabeth following an accident whilst boarding from a tender.

[32] Special guests include Captain Ian McNaught, Commodore Ronald Warwick, Maritime Historian Chris Frame and QE2 Social Hostess Maureen Ryan.

[34] On 23 May 2019, Queen Elizabeth began regular service between Vancouver, British Columbia, Canada and various destinations in Alaska, United States.

[36][37][38] On 24 February 2020 Queen Elizabeth was denied permission to dock in Rabaul by the  Governor of East New Britain Province, Papua New Guinea due to their growing concerns regarding the COVID-19 pandemic.

[43] Queen Elizabeth was initially moored offshore near Newcastle, Australia, before departing for Manila Bay, Philippines, to anchor with a number of other cruise ships.

[46] Resumption of cruising by Queen Elizabeth, scheduled for 19 July 2021, was delayed due to a small number of crew contracting COVID-19.

[48] On 28 November 2021 the Queen Elizabeth was unable to dock in Southampton due to the extreme weather of Storm Arwen causing the next voyage to be cancelled.

[61] On 27 November 2022, Queen Elizabeth was prevented from visiting Bali, Indonesia, due to some passengers testing positive for COVID-19, and was diverted to Fremantle but was then able to continue the scheduled cruise around Australia.

[62] In January 2023, the Queen Elizabeth was forced to skip visits to Fiordland, including Milford Sound, and Dunedin in New Zealand due to biofouling concerns.

On 16 March 2023, the Queen Elizabeth entered Sembcorp Marine Shipyards drydock for scheduled maintenance in preparation for the North Pacific summer cruise season.

[69][70][71] To celebrate the Coronation of King Charles III on 6 May 2023, the Queen Elizabeth channeled the ceremony live from Westminster Abbey into the ship's Royal Court Theatres and stateroom TVs.

[79] In October 2024, along with the Norwegian vessel Lodbrog, the Queen Elizabeth responded to the mayday and eventual sinking of the Royal New Zealand Navy ship HMNZS Manawanui off the coast of Samoa.