The 2006 VMALAs (Premios MTV Latinoamérica) were held in Mexico City, and therefore were the first ones to actually be celebrated in Latin America.

Created in 2002, the VMALAs were held in the Jackie Gleason Theatre in Miami Beach, Florida until 2004.

In 2005 the awards were to be held Wednesday, October 19 at the Xcaret Park's Great Tlachco Theater in Playa del Carmen (close to Cancún), Quintana Roo, Mexico, for the first time in a different location since their creation.

However, due to the approach of Hurricane Wilma towards the Mexican Riviera Maya, the show was moved from October 20 to the 19th, but it was eventually postponed.

A couple of months later, MTV decided that it was not feasible to have the show on the aforementioned scheduled date.

The 2005 edition would have included performances by Shakira, Sean Paul, My Chemical Romance, Foo Fighters, Ricky Martin, Simple Plan, Miranda!, Babasónicos, Belinda, and Good Charlotte.

On July 21 MTV Latin America announced that the 2006 ceremonies would be held on 19 October 2006 in Palacio de los Deportes indoor arena in Mexico City.