It was released on 23 November 2024 as part of the soundtrack to the second season of the Netflix animated series Arcane (2024), and later impacted Italian radio on 6 December, through Riot Games and Virgin Music.

The song was written by the artists alongside Alexander Seaver, as well as Stromae's brother and long-time collaborator Luc Van Haver.

On 23 November 2024, Stromae took to social media to announce his collaboration with Pomme, saying they "crafted a special song" for the final season of the series Arcane, which was released on Netflix the same day.

[1] The song marks the return of the singer following a two-year break from music and the cancellation of his Multitude Tour in early 2023 due to health reasons.

[2] "Ma meilleure ennemie" plays during the seventh episode of Arcane's second season and accompanies a key scene that sees the characters Ekko and Powder dancing.