The MacPherson Single Member Constituency is a single member constituency located in the central area of Singapore.

It is managed by Marine Parade Town Council.

The current Member of Parliament for the constituency is People's Action Party (PAP) Tin Pei Ling.

It existed from 1968 to 1991 as an independent ward, was merged with Marine Parade GRC until 2011, and became an independent SMC again for the 2015 general elections.

The ward consists of Circuit/Pipit Road, Geylang East Central, Aljunied Crescent/Avenue 2, Mattar/Merpati Road, Paya Lebar MRT/Square and several areas near MacPherson.