[2] Born on 2 February 1978 in Córdoba,[3] she joined the Maruja Caracuel's Ballet School at a young age.

[4] She trained for three years at the Rose Bruford College of Speech and Drama in London, moving to Madrid afterwards.

[4] After some minor roles in television starting in 1999 (Raquel busca su sitio, El comisario),[5] her film debut was the 2001 cosmic horror movie Dagon,[3] portraying mermaid-like priestess Uxía Cambarro.

[6][7] By the end of 2013, right after the beginning of the new season of the soap opera La que se avecina, Macarena Gómez starts presenting TV commercials for the Spanish banking group Bankia.

In 2018 she played Dolores in the biography drama historical film El fotógrafo de Mauthausen along with Mario Casas and Alain Hernández.