Macau participated in the inaugural 2006 AFC Challenge Cup held in Bangladesh being grouped with Kyrgyzstan, Tajikistan and Pakistan but lost all of their match against their opponent.

Macau then participated in the inaugural 2016 AFC Solidarity Cup held in Kuching, Malaysia being grouped with Laos, Mongolia and Sri Lanka.

After a 4 years hiatus from the COVID-19 pandemic, On 26 March 2023, Macau play their first ever international matches at their own ground,Estádio Campo Desportivo against Singapore in a 1–0 defeat.

In August 2024, all non-Chinese nationals listed to play for the Macau Football Association became ineligible for the team under FIFA Congress's adoption to a rule amendment made in 18 September 2020.

[5] In September 2024, Macau signed a deal with Adidas in preparation for the 2027 AFC Asian Cup qualification – play-off round ending their 10-years partnership with Nike.

In 2005, Macau was temporarily barred by FIFA from entering any international matches because of alleged undue influence of the government in forming the committee of its football association.