[4] It is located in the southwest corner of Wayne County and contains a hamlet also named Macedon, formerly an incorporated village.

[5] It has the same root as the adjective μακρός (makros), meaning "long" or "tall" in Ancient Greek.

[5] The name is originally believed to have meant either "highlanders", "the tall ones", or "high grown men".

[6] Prior to early settlement, the area in and around Macedon was home to the Seneca Nation, a tribe member in the Iroquois League.

[7] The town land was acquired for settlement in 1788 from the Commonwealth of Massachusetts as part of the Phelps and Gorham Purchase.

[8] The opening of the Erie Canal led to the forming of new port communities like Wayneport and the Village of Macedon, with the latter centered on Lock 30.

Part of Company B, 160th New York Volunteer Infantry, was raised in Macedon during the American Civil War.

[11] The J. and E. Baker Cobblestone Farmstead and Charles Bullis House are listed on the National Register of Historic Places.

Small specialty shops and boutiques are available in the old village on Main Street and near Canandaigua Road.

To the west, Lowe's and Wal-Mart Superstores, and the surrounding area near Wayneport has grown more attractive to other businesses and developers.

Newer businesses in the area include The Purple Painted Lady®, Macedon Family Chiropractic, Twisted Rail Brewing, and Cherry Creek Siding & Windows L.L.C.

The fourth area surrounds the Gananda planned community offering daily services and offices.