The under-21 age category came into existence with the realignment of UEFA's youth competitions in 1976.

Four months later, Macedonia also had their first competitive match which ended in a 5–3 win against Denmark.

So far, the team has qualified for one final tournament, the one being the 2017 Euro U21 held in Poland for players born 1994 or later.

They ended the tournament on the 11th position with 1 draw and 2 losses over the group stage.

Players that have been called up within the past 12 months and are eligible for the 2023 European U21 Football Championship Qualifiers.