[1] The IIsi remained on the market for two and a half years and was discontinued shortly after the introduction of its replacement, the Centris 610.

David Pogue's book Macworld Macintosh Secrets observed that one could speed up video considerably if one set the disk cache size large enough to force the computer to draw video RAM from the faster RAM installed in the SIMM banks.

This problem was caused by the very modular construction of the computer, where the mono loudspeaker is on a daughterboard under the motherboard, with springy contacts.

The problem could be solved by removing the motherboard and using a pencil eraser to clean the contacts of the daughterboard holding the loudspeaker.

The IIsi was designed to be easily and cheaply manufactured, such that no tools were required to put one together – everything is held in place with clips or latches.