Macomber Stone House is a historic home located in Duanesburg in Schenectady County, New York.

It was built about 1836 and is a two-story, five-bay, center hall vernacular Federal style dwelling with a gable roof and narrow cornice.

It is constructed of field dressed random ashlar, local limestone.

Also on the property are three contributing 19th century frame barns with clapboard siding.

[2] The property was covered in a 1984 study of Duanesburg historical resources.