Epiretinal membrane or macular pucker is a disease of the eye in response to changes in the vitreous humor or more rarely, diabetes.

These cells can form a transparent layer gradually and, like all scar tissue, tighten to create tension on the retina which may bulge and pucker, or even cause swelling or macular edema.

Often this results in distortions of vision that are clearly visible as bowing and blurring when looking at lines on chart paper (or an Amsler grid) within the macular area, or central 1.0 degree of visual arc.

The distortions can make objects look different in size (usually larger = macropsia), especially in the central portion of the visual field, creating a localized or field-dependent aniseikonia that cannot be fully corrected optically with glasses.

Small breaks in the internal limiting membrane (ILM) after PVD also may provide retinal astrocytes access to the vitreous cavity, where they may subsequently proliferate.

Usually there are flashing-light experiences and the emergence of floaters in the eye that herald changes in the vitreous before the epiretinal membrane forms.

January 10, 2004), an American actor, screenwriter, and playwright, released Gray's Anatomy, a film monologue describing his experiences dealing with a macular pucker and his decision to undergo surgery.

In the 2011 film Paul, Ruth had epiretinal membrane complicated by macular edema in her left vitreous cavity.