Notable guest stars this season include: Dwayne "The Rock" Johnson, Eva Longoria, Seth MacFarlane (who, back when MADtv was starting out, was offered the chance to produce animated shorts for the show), the Los Angeles Kings, Tom Bergeron, Efren Ramirez, and Fred Willard.
A parody of "The Sweet Escape" has Gwen Stefani (Parker) in love with East Asians and all they've contributed to society; the doctors from Grey's Anatomy summon Dr. Gregory House (McDonald) to cure a woman who's foaming at the mouth; Flavor Flav (Peele) recounts skewed versions of famous moments in African-American history, much to Sidney Poitier's (Key) chagrin; another episode of the Korean soap opera Attitudes and Feelings Both Desirable and Sometimes Secretive; Ellen DeGeneres (Parker) interviews Salma Hayek (Donovan); animated piece where Cupid's attempt to make a love connection turns deadly when he uses hollow-point arrows; Ike Barinholtz's visit with Bobby Lee's parents turns nightmarish when the family creeps him out.
Kevin Federline (Barinholtz) shows off new Amway products while Britney Spears (Parker) is restrained Hannibal Lecter-style; a country singer (Peele) performs a song about Yao Ming (Lee); Steve Jobs' (McDonald) sales pitch for the iRack mirrors America's disastrous occupation of the similarly-named country; Heidi Klum (Flanagan) is miscast as a silent secret agent; Rob Corddry plays an employee who tells a fellow co-worker (Barinholtz) about his recent tryst with another co-worker (Peele); an ocean institute doctor (McDonald) freaks out when one of his sharks goes on a rampage on a Discovery Kids Shark Week show; psycho Catholic school coach Hines (Key) works at an ice cream parlor for an after school job; On Celebrity Pets, Lindsay Lohan's dog Chloe (voice of Crista Flanagan) misses her master; blaxploitation parody in which Condoleezza Rice (Johnson) investigates why black people are being irradiated; a commercial for Glad bags portrays the announcer wishing for a small device; a simple argument between a grandmother (Flanagan) and her granddaughter (Myrin) erupts into a brawl; an elderly woman (Johnson) annoys a video rental outlet employee (Key).
Nicole Parker objects to Crista Flanagan, Lisa Donovan, Arden Myrin, and Nicole Randall Johnson acting out sexual fantasies for ratings; parody of Heroes trashes the show for being cliched and overrated; a family (Barinholtz, Donovan, McDonald) stages an intervention to stop their cousin (Caeti) from speaking in a stereotypically Italian voice, only to learn that his real voice is worse; while promoting his new album Reborn, Seal (Peele) is constantly interrupted by his shrill-voiced wife Heidi Klum (Flanagan); a hungover co-worker (Parker) running late for work delivers a poorly-produced PowerPoint presentation; three alternate endings of Gone with the Wind; Eugene Struthers (Key) delivers flowers to Leah Remini; E.R.
The Blind Kung Fu Master (Lee) tries to save a princess (Myrin) from an evil sorcerer (Key); King Henry (McDonald) finds work as a fast-food employee on The King Henry Show; Coach Hines (Key) threatens prom attendees and gets drunk; Fred Willard plays a sarcastic preacher who hosts a roast for Jesus Christ; Tori McLachlan (Parker) sings a depressing song about life after high school; a parody of I Shouldn't Be Alive features different re-enactments of the same story; Astroman (Barinholtz) confronts his rival Killbrain the Fury (Peele); on the final installment of Celebrity Pets, Kim Jong-Il's dog dispels rumors about the dictator; the Jazzed for Crafts girls (Flanagan, Myrin) meet cute with a rental store employee (Peele).