[1] Her work in synthesizing organic compounds such as tilorone, furanomycin, and numerous cyclopeptides has led to the development of antibiotic and antiviral drugs.

[2] Joullié has received numerous awards, including the 1978 Garvan Medal from the American Chemical Society, in recognition of her accomplishments in teaching and research.

[3] Originally in a non-tenure-track position, Joullié taught undergraduate organic chemistry five days a week and ran the lab.

[3] Joullié was active in the safety committee at UPenn, helping to identify and enforce safe work guidelines for the chemistry department.

[1][5] Between 1976 and 1980, Joullié reviewed the hiring and promotions processes of the School of Arts and Science, comparing resumes of male and female candidates.

Her effectiveness in the position led Provost Eliot Stellar to appoint her as the chair of the university's Council for Equal Opportunity, overseeing affirmative action in all departments.

[5] Of her affirmative action activities, Joullié says: "I served in that role for seven years, without help, extra pay, or teaching relief...

"[4] Described by professor Helen Davies as "fearless and formidable",[5] Joullié is credited as having played a key role in creating a culture of equality for women at the university.

She also did significant research on heterocyclic ketones in the 1970s, collaborating with Peter Yates of the University of Toronto, and receiving the 1972 ACS Philadelphia Section Award.

Her subsequent work has led to the total synthesis of several natural products, including muscarine, geiparvarin, ascofuranone, furanomycin, and dihydromauritine A.

[1] Working with Judah Folkman at Harvard Medical School and Paul B. Weisz at the University of Pennsylvania, Joullié helped to synthesize beta-cyclodextrin sulfate, a ring-shaped sugar molecule that attaches to the walls of growing blood vessels.

Beta-cyclodextrin sulfate is also useful in limiting restenosis, growth of cells on artery walls that can lead to blockages at the site of surgical procedures.

Joullié's asymmetric total synthesis of didemnin B in 1990 was a landmark event leading to fundamental contributions to both the chemistry and biology of this intriguing class of natural products.