[not verified in body] Her career started with Lorema FC and Canon Yaoundé, winning the domestic cup and league twice each in Cameroon .

[3] After the domestic success, she joined RC Saint-Étienne in 2003, then in the fourth tier of French football.

The team merged with AS Saint-Étienne in 2009, after their exploits leading them to the top level of French football, in no small part due to Ngono Mani's goal-scoring abilities.

[11] In the 2012 Summer Olympics in London, United Kingdom, she played all three matches of the group stage of the women's football tournament, but the team did not manage to gain a single point and failed to qualify for the following round.

She played a key role in Cameroon's campaign in the 2015 FIFA Women's World Cup, scoring a header to complete a comeback win against Switzerland,[12] as well as scoring in the 6–0 rout of Ecuador.