The swath of land between Johns Hopkins Hospital and Frank C Bocek Park, which includes Madison-Eastend, is often referred to as the "Down the Hill" neighborhood by local residents.

There is a brownfield in Madison-Eastend due to environmental contamination caused by factories, refineries, and other businesses polluting the land and water.

The district is historically significant due to the large Czech-American (Bohemian) immigrant community that once lived in the area.

[4] In the late 1800s and early 1900s, the Bohemian stronghold north of Johns Hopkins Hospital along the Baltimore to New York Amtrak line all the way to Frank C Bocek Park was known by the now mostly forgotten name of "Swampoodle".

[6] The heart of the Bohemian "hollow" of Swampoodle was located just north of Johns Hopkins Hospital along the tiny side streets of Barnes and Abbott.