[1][2] The route consists of a leg originating in Downtown Baltimore and goes on to serve the Garrison Boulevard corridor in the northwest of the city.

[4] It has followed essentially the same route throughout its lifetime since then, only with the modification of service operating via the Rogers Avenue Metro Subway Station full-time.

This plan was scrapped as a result of public outcry, especially because no bus service would have been provided on Eutaw Place in Bolton Hill.

In 2015, Governor Larry Hogan announced an initial proposal for an overhaul to the local bus system in Baltimore which constituted a drastic transformation of the network.

Residents of Northwest Baltimore noted that service along Garrison Boulevard between Walbrook and Rogers Avenue Metro station was proposed to be eliminated, and State Senator Lisa A. Gladden spoke out against the proposal, stating that it would be unfair to leave residents of her district with walking long distances along Garrison or from a stop on a route serving another corridor.

[9] The LocalLink 80 is one of the routes the MTA has selected as a candidate for making substantial infrastructure changes to the roads it travels on, based on assessments of inefficiencies introduced by the built environment and on the amount of riders who would stand to benefit from improved service.