The Madison County Sheriff's House and Jail was a historic house and jail building located at 210 N. Main St. in Edwardsville, Illinois.

The building consisted of a three-story sheriff's house and an adjacent cell block; the cell block was expanded in 1904 to provide space for female prisoners.

The building's design featured a mansard roof, two dormers on both the front and rear sides, and a bracketed wooden cornice.

[2] The building was added to the National Register of Historic Places on May 31, 1980,[1] and was delisted in 2020.

This article about a property in Madison County, Illinois on the National Register of Historic Places is a stub.