Madonna and Child with Saint James and Saint Dominic

[3] It was commissioned for his family chapel by Jacques Florence (in Flemish Jacob Floreins), a spice merchant in Bruges, who died there in 1488.

[6] The work may have inspired Hans Holbein the Younger's Darmstadt Madonna[7] and its portrayal of a husband and wife facing each other with their children has also been compared with the Funk family epitaph attributed to Bernhard Strigel and now in the Schaffhouse in Switzerland, though this latter work lacks the saints and the Madonna and Child.

Memling's work seems to have been taken to Spain thanks to the wishes of Jacob Floreins' Spanish widow, whose family was based in Burgos.

General Jean Barthélemy Darmagnac was based in Burgos and looted the painting from there in 1808 during the French occupation of Spain.

It was then acquired from him by count Duchâtel, whose wife then left it to its current owner in 1878.