The Madonna and Child with Saints Luke and Catherine of Alexandria, also known simply as Holy Conversation, is a painting by the Italian Renaissance master Titian.

[2] The Madonna and Child with Saints Luke and Catherine of Alexandria is a mature work executed when Titian was at the height of his artistic powers and fame.

[3] The painting remained in the Dondi dell'Orologio family until Sir Richard Worsley purchased it during his stay in Italy as the last British Resident of Venice,[5] a position he held from 1793 to 1797.

She frequently hosted meetings of the celebrated aristocratic, political and literary figures known as "The Souls" at the Desborough residence, with visitors including Henry Irving, Vita Sackville-West, Edward VII, H. G. Wells, Edith Wharton and Oscar Wilde.

[8] The painting achieved the highest auction price ever for one of Titian's works, at $16.9 million, when it was sold at Sotheby's to a European telephone bidder on 28 January 2011.