The Madrid–Valencia de Alcántara line is an Iberian-gauge railway in Spain owned by ADIF.

It is one of the main legacy lines across Extremadura and the province of Toledo, serving cities such as Talavera de la Reina and Cáceres.

Part of the stretch across the Madrid region (up until Humanes) is used by commuter service C-5..

[5] The aforementioned double-track electrified stretch is integrated in Cercanías Madrid's service C-5.

[6] Starting from the boundary of the municipality of Humanes, the railroad line continues without electrification on a single track.