The nephew of Renaissance humanist and statesman Peter Agricola, he became church minister as well as superintendent and ecclesiastical inspector at Neuburg an der Donau (Bavaria).
On January 10, 1586 at Lauingen, Agricola married Anna Maria Motz, whose father was a former student of the University of Tübingen and the princely chief tax collector of Pfalz-Neuburg.
Motz's brother-in-law (and friend of Agricola) was Dietrich (Theodor) Hess, councilor of the reigning Duke of Neuburg, diplomatic envoy to Denmark and the Court of St. James (London), and permanent ambassador to the Court of France in Paris under King Henri IV and Queen-regent Mary de Medici.
He showed promise, so in 1575, Prince Philip Louis, Count Palatine of Neuburg sponsored Agricola's ongoing theological studies.
Agricola held a number of ecclesiastical posts (Pfarrer, Konsistorialrat, Inspektor, Kirchenrath, Konsistorialassessor) in Neuburg an der Donau, Bavaria in a career spanning three decades.
Among them was Von der Katholischen Christlichen Lehre Augsburgischer Konfession, und dem Unkatholischen Heydensüchtigen Papstum, a book of some 300 pages published in 1599 and re-published in 1602.