After spending 1837–1838 in Germany, Austria and France for his scientific studies, he was appointed assistant chief physician at the Serafimerlasarettet in 1839 with the support of anatomist Anders Retzius and surgeon Carl Johan Ekströmer [sv].

[6] At this clinic the methods of physical examination were introduced, including auscultation and percussion,[7] in conjunction with a more careful study of pathological anatomy; and by the extraordinary ability and perseverance which Huss developed during his long service as director of the clinic, the above date may be said to form a turning point in the history of Swedish medicine.

In 1860 he was appointed chairman of the Sundhetskollegium (later the National Swedish Board of Health) and general director of the hospitals, lazarettos and sanatoriums in the kingdom.

Huss gained his greatest scientific fame from the 1854 Montyon Prize awarded by the French Academy of Sciences for Alcoholismus chronicus eller chronisk alkoholssjukdom (Alcoholismus chronicus or chronic alcohol disease; two volumes, 1849–1851), in which the pathological changes in the body caused by chronic alcohol intoxication were first listed as a separate form of disease.

[5] In addition to these works, Huss published in journals a number of major and minor papers, edited financial accounts of the Serafimerlasarettet from 1850 to 1860, and of Crown Princess Louise's Hospital for Sick Children (Kronprinsessan Lovisas vårdanstalt för sjuka barn) from 1852 to 1864, as well as Öfverstyrelsens öfver hospitalen underdåniga berättelser (the Head board's subordinate accounts of the hospitals) 1861–1876.

In 1865, Huss published the popular work Om kaffe; dess bruk och missbruk (On coffee; its use and abuse).

Thus it was at his and Carl Peter Dahlgren [sv]'s instigation that Crown Princess Louise's Hospital for Sick Children came into being.

[13][11] He was also energetically active in the reorganization of the Allmänna Barnhuset in Stockholm, the establishment of children's nurseries and improved legislation concerning the care of the mentally ill.

He took the initiative for Sweden's first children's nursery, Kungsholmen barnkrubba [sv], inspired by similar establishments in Paris.

[5] Excerpts from Huss's surviving manuscript were published in 1891 under the title Några skizzer och tidsbilder från min lefnad (Some sketches and moments from my life).