The town continued to exist, growing as a trading center, and was granted city privileges sometime in mid-16th century.

At the time it was a royal city and Grand Duke of Lithuania Sigismund I the Old built a castle for his Italian wife Bona Sforza.

After extinction of the Jagiellon dynasty, Maišiagala lost its status as royal summer residence and began to decline.

[2] In 1805 the Houvalt family bought the town from heirs of Ignacy Massalski, Bishop of Vilnius.

At the end of September 1941, at a small town next to Maišiagala called Vilnova, the rest of the Jewish population was murdered by the German and Local police.