[2][3] The district was listed on the National Register of Historic Places on October 3, 1985.

[1] It covers 6.5 acres (2.6 ha) and contains five historically significant contributing properties, all predating the American Civil War.

[1][3] Gainesville lies on the south bank of the Tombigbee River in southwestern Alabama.

It reached its zenith prior to the American Civil War; when it was an important inland port, before the wide-scale introduction of railroads.

[2] Media related to Main–Yankee Street Historic District at Wikimedia Commons