The Main Building of the U.S. Bureau of Mines is the former main building of the United States Bureau of Mines Central Experiment Station.

It was listed on the National Register of Historic Places in 1974.

[1] Located in the Squirrel Hill North neighborhood of Pittsburgh, Pennsylvania, this historic structure was built between 1915 and 1917 and dedicated on September 29, 1919.

The university purchased the complex from the Bureau of Mines in 1985.

The main building was listed on the National Register of Historic Places in 1974.