The Main Central Road popularly known as MC Road is the arterial State Highway starting from Kesavadasapuram in Trivandrum city and ends at Angamaly, a suburb of Kochi city in Ernakulam District, in the state of Kerala, India.

This road starts from National Highway 66 at Kesavadasapuram in Thiruvananthapuram the capital city of Kerala and joins the NH 544 at Angamaly[1] Ernakulam district.

The MC Road passes through Venjaramoodu, Kilimanoor, Nilamel, Chadayamangalam, Ayoor, Kottarakkara, Enathu, Adoor, Pandalam, Chengannur, Tiruvalla, Changanassery, Kottayam, Ettumanoor, Kuravilangad, Monippally, Puthuvely, Koothattukulam, Meenkunnam, Muvattupuzha, Pezhakkappilly, Mannoor, Pulluvazhy, Perumbavoor and Kalady.

Under phase 1, two stretches, Thaikkod (near Venjarammoodu) – Chengannur and Muvattupuzha – Angamaly were upgraded and works were completed in 2010.

[2] The Motor Vehicles Department, in partnership with the Kerala Road Safety Authority (KRSA) and the police has installed automatic traffic enforcement camera systems in between Venjaramoodu - Chengannur section of MC road for detecting speed violations of vehicles.