Main Street Commercial Historic District is a national historic district located at Hamlet, Richmond County, North Carolina.

It includes buildings built between about 1900 to about 1940 and notable examples of Queen Anne, Art Deco, and Classical Revival architecture.

Located in the district is the separately listed Seaboard Air Line Passenger Depot.

Other notable buildings include the Terminal Hotel (c. 1912), Union Building (c. 1920), the Bank of Hamlet (1912), the Old Hamlet Opera House (1912, 1927), and the U.S. Post Office (1940), a Works Progress Administration project.

This article about a property in Richmond County, North Carolina on the National Register of Historic Places is a stub.