The Mainz–Worms–Ludwigshafen Railway connects Mainz via Worms to Ludwigshafen in the German state of Rhineland-Palatinate From there trains cross the Rhine via Mannheim or run south towards Speyer.

In 1845, the Hessian Ludwig Railway Company (German: Hessische Ludwigsbahn) received a concession to build and operate this route.

The first section of the line between Mainz and Worms was opened on 23 March 1853 and it was completed to Ludwigshafen on 15 November 1853.

A number of long-distance Intercity or Intercity-Express trains run from Koblenz or Wiesbaden on the Mainz-Mannheim line.

The Regional-Express service from Mainz via Ludwigshafen am Rhein to Karlsruhe (RE 4) and Mannheim (RE 14) have also been operated since December 2014[2] as part of the Süwex network with class 429 railcars.