As one of the most heavily used roads in Frankfurt, factories soon sprang up along its length as Germany industrialised in the 19th century, including the headquarters of Adler and Tenovis.

From the Innenstadt, Mainzer Landstraße runs through Westend, Bahnhofsviertel, Gallus, Griesheim and Nied on the way to Höchst.

The road begins at Taunusanlage station, close to the Deutsche Bank Twin Towers.

Between Taunusanlage and the crossroads at Platz der Republik, it passes the Westend Tower, the Frankfurter Büro Center and the City-Haus.

This road, and its continuation Brüningstraße, runs through the old town and Industriepark Höchst, the headquarters of Hoechst AG.