Her work has been focused on the defense of the Rule of Law and fundamental rights, as well as the fight against terrorism, foreign interference and harmful disinformation aimed at overthrowing democratic systems.

After years of harassment, persecution and aggressions and, especially after the murder of her brother Joseba, she moved with her family, on police recommendation, out of the Basque Country in 2007.

The cost of her public stance in the front line against terrorists meant a high degree of harassment, threats and aggressions of physical and symbolic violence, forcing her to live under police escort for 13 years.

Her activity has been recognized with multiple awards such as the Sakharov Prize for Human Rights in 2000 - as a founding member of ¡Basta Ya!- or the Medal of the Order of Constitutional Merit in 2003.

Subsequently this divide grew further, due to the anti-terrorist policy undertaken by the government of José Luis Rodríguez Zapatero and the PSOE, as well as the relations of Patxi López and the PSE-EE with the Basque nationalist and abertzale environment, showing her reticence towards the contacts maintained with Batasuna and the political negotiations with ETA and its environment, after the "so-called" permanent ceasefire announced by ETA.

In May 2005, together with the widow of her brother Joseba Pagazaurtundúa, Estíbaliz Garmendia, the also socialist councilman in Miravalles, Nicolás Gutiérrez, the then PSOE MEP Rosa Díez, the philosopher Fernando Savater and the professor Mikel Iriondo, she sent an open letter to Patxi López reproaching him for the treatment given to María San Gil, of the Popular Party, in front of the EHAK parliamentarians, in his round of parliamentary contacts.

On February 5, 2014, she announced together with Rosa Díez that she would run for the European elections in the number 2 position on the UPyD list as an independent, just after Francisco Sosa Wagner,[5] to whom she later dedicated a fisking.

[10] Other prominent members of the initiative were Fernando Savater, Joseba Pagazaurtundúa (murdered by ETA in 2003), Consuelo Ordóñez, Arcadi Espada, Carmen Iglesias, Javier Urguizu, Mikel Azurmendi, Iñaki Ezkerra, Agustín Ibarrola, María San Gil and Rosa Díez.

This initiative was characterized by bringing to the field of the defense of liberties and fight against terrorism novel and dynamic forms of activism and vindication: demonstrations,[11] caravans,[12] poster sticking, publication of the online magazine "Hasta aquí" (Up to here)...

On December 13, at a solemn session in Strasbourg, the prize was collected by the philosopher Fernando Savater, the natural leader of the group, who explained the reason for the initiative:¨We have taken to the streets and raised our voices because we are convinced that, when democracy is in danger, citizens cannot take refuge in their anonymity and meekly wait for everything to be resolved in the upper echelons of political power.

She hired a young lawyer to corroborate the data and led, with a group of victims, the constant work for more than two years to make the Audiencia Nacional (National Court) aware of the situation.

Finally, the Prosecutor's Office of the Audiencia Nacional, with Javier Zaragoza at the head, produced the first official table of cases whose material authorship of murder was not resolved.

Pagazaurtundúa herself appealed to all those who felt challenged by the mailbox to deposit their letters -anonymous if they preferred- acknowledging their share of responsibility for the harassment and persecution of so many people.

In addition, the physical mailbox has subsequently been completed with a virtual one (http://www.elbuzondejoseba.org/) that has allowed the message for collective memory and against impunity to reach all corners of Spain.

Her work  continued to be committed to the defense of freedom, the fight against terrorism and radicalization or the promotion of human rights and justice, as well as the quality of the rule of law against the risks of illiberal populisms of all types.

Pagazaurtundúa has advocated building bridges between different political groups and finding pragmatic solutions to the challenges facing the European Union to advance the human rights, security and justice agenda in Europe.

As a member of the Committee on Petitions, the only parliamentary committee to which European citizens can address their complaints and grievances, Pagazaurtundúa has promoted and been part of several delegations of MEPs who have traveled to Spain to investigate situations of violation of civil liberties and fundamental rights, which have led to condemnations by the European Parliament in its reports: Pagazaurtundua has carried out work to protect the rule of law and the separation of powers as a European matter, defending the independence of the judiciary on the basis that it is the backbone of the rule of law, since it is a precondition for guaranteeing effective judicial protection and avoiding arbitrariness and abuses by any government or public power.

Her work prompted the European Parliament to denounce in the INGE Committee reports the "close and regular contacts between Russian officials and representatives of a group of Catalan secessionists in Spain", requesting "an in-depth investigation" and noting that these "form part of Russia's broader strategy to seize any and every opportunity to manipulate the discourse in order to promote destabilization".

To do so, she joined intellectuals and writers such as Mario Vargas Llosa, Alberto Barrera Tyszka, Juan Carlos Méndez Guédez, Doménico Chiape, Oscar Lucien.

In January 2022, she organized at the European Parliament a commemoration of ¡Basta ya!, which included the installation of the "tunnel of hate",[23] curated by José Ibarrola, a sensory experience where the sound of hatred reproduced the oppression and harassment of exclusionary ethno-nationalism that terrorized for decades the streets of the Basque Country and Navarra and some brave citizens who rise with the Sakharov Prize of the European Parliament.

She has received numerous awards and acknowledgments for her work: From her office in the European Parliament, Pagaza has carried out different initiatives, studies, reports and audiovisual content pieces.

The aim of this study, published both in print and website, is to contribute to the realization of a heat map constituting a wake-up call on the growing phenomena of hate.