Mandžuka graduated at University of Art/TV and movie production in Belgrade, then in 2006 she moved to New York where she attended The Lee Strasberg Theatre and Film Institute.
Mandžuka 's first public appearance came at the age of 12, when she was selected as a model for a New Year's edition of Greek magazine "Selides".
Her most popular performance came in 2001 with the lead female role of Kata in the Serbian hit movie Munje!
The movie broke all theater attendance records in Serbia and propelled Mandžuka to stardom at the age of 19.
During this time she was also playing in the popular TV show Treci Kanal od Sunca (Third Channel From the Sun).
She has stated that she enjoys traveling, tennis, reading, wine tasting, spending time with friends and playing with her two nephews.